On November 22, the 141st "Innovation, Creation and Entrepreneurship" high-end forum was held in HZAU. The forum was jointly hosted by the State Key Laboratory of Agricultural Microbiology, the Key Laboratory of the Ministry of Education of Agricultural Animal Genetics and Breeding and Reproduction, the Collaborative Innovation Center of Health Pig Breeding and the College of Animal Sciences and Technology. Ding Xianting, a researcher at Shanghai Jiao Tong University and Li Pilong, a researcher at Tsinghua University were invited to discuss relevant academic issues with more than 40 teachers and students at the scene and make reports.
Ding Xianting first made related reports about four different research directions including AI technology combination drug optimization, single cell flow mass spectrometry technology, tissue section topology technology and single cell Western blot technology. He combined the current situation of clinical treatment with systematic intervention and multi-point corner treatment and used the experimental results in the long-term stem cell culture and other experimental researches to explain several advantages of AI technology, such as clinical practicability, economy and thorough durability. In response to the bottleneck problem of overlapping fluorescence spectrums in traditional cell flow technology, he pointed out that the new single cell flow technology which relies on metal element coupling group has the advantages of low background, no cross color and multiple channels, and can effectively solve the related problems of traditional cell flow technology. Meanwhile, he also gave a report on the innovative technology of tissue slice and the new technology of Western blot, and then discussed with the teachers and students on site.
Li Pilong’s report described the formation mechanism of liquid-liquid phase separation (LLPS) and regulation of LLPS in the formation of heterochromatin. He pointed out that LLPS has a long history in polymer chemistry research, but it is still an emerging field in biology. LLPS produced by multivalent interaction is the main driving force of many membrane-free organelles in cells. In response to the question of how heterochromatin is regulated by LLPs derived from the multivalent interaction between the inhibitory epigenetic modifying element and its reader protein, and how pathogenic genetic variation affects the normal LLPS state, he believed that heterochromatin formation is associated with histone modification-mediated LLPS.
Translated by Wei Meiqi
Proofread by Xie Lujie
